Sudden Death after Intravenous Injection of a Mercurial Diuretic

A New Oral Mercurial Diuretic - Merpurate Table

OU RAL administration of diuretics with a safe and satisfactory diuresis has always been a therapeutic goal. Diuresis could then be accomplished at a slow but regular rate, with the avoidance of a sudden profuse diuresis,' which is very uncomfortable for the patient, and produces marked alteration of the fluid and electrolyte balance. Rapid diuresis has been known to cause attacks of gout,2 tet...

Death from pulmonary microembolisation after intravenous injection of temazepam.

Dr E J VELLA (Pathology Laboratory, Lakin Road, Warwick CV34 5BJ) and Dr C W EDWARDS (Departme9e of Pathology, East Birmingham Hospital, Birmingham B9 5ST) write: A 31 year old female drug misuser presented with pain in her right leg. She told the casualty doctor that a few hours previously she had crushed a few 10 mg tablets of temazepam, dissolved them in water, and injected the solution intr...

The nephrotic syndrome complicating mercurial diuretic therapy.

Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs

Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non...

An Unusual Case of Hypersensitiveness to a Mercurial Diuretic *

The occurrence of toxic reactions following the administration of mercurial diuretics is well known. Most authors divide the reactions into two categories, those which are immediate, and the delayed. It is the general agreement that the immediate, fatal reaction occurs only after intravenous administration of the drug.1 2' 5,6, 8. 9, 12, 17, 20, 21 Tnere iS abundant evidence, both clinical and ...